
P-gp inhibitor 1
CAS No. 2050747-49-2
P-gp inhibitor 1 ( —— )
产品货号. M26354 CAS No. 2050747-49-2
P-gp 抑制剂 1 抑制逆转 P-糖蛋白介导的多药耐药性,EC50 为 57.9 nM(K562/A02 细胞)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1037 | 有现货 |
![]() ![]() |
10MG | ¥1725 | 有现货 |
![]() ![]() |
25MG | ¥3467 | 有现货 |
![]() ![]() |
50MG | ¥5176 | 有现货 |
![]() ![]() |
100MG | ¥7209 | 有现货 |
![]() ![]() |
500MG | ¥14823 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称P-gp inhibitor 1
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述P-gp 抑制剂 1 抑制逆转 P-糖蛋白介导的多药耐药性,EC50 为 57.9 nM(K562/A02 细胞)。
-
产品描述P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).(In Vitro):In K562/A02 MDR cells, P-gp inhibitor 1 (0.1, 1, 5 μM, 1 h) boosts the potency of other MDR-related cytotoxic agents with different structures, increases the accumulation of DOX, blocks Pgp-mediated Rh123 efflux, and suppresses P-gp ATPase activity.
-
体外实验P-gp inhibitor 1 (12k) possesses high potency (EC50=57.9±3.5 nM), low cytotoxicity, and long duration of activity in reversing doxorubicin (DOX) resistance in K562/A02 cells (1 μM, 80 minutes). P-gp inhibitor 1 also boosts the potency of other MDR-related cytotoxic agents with different structures, increases accumulation of DOX, blocks Pgp-mediated Rh123 efflux, and suppresses P-gp ATPase activity in K562/A02 MDR cells (0.1, 1, 5 μM, 1 hour). Western Blot Analysis Cell Line:K562/A02 cell Concentration:0.1, 0.5, or 2.0 μM Incubation Time:72 hours Result:MDR reversal by 12k was not caused by a decreased protein expression but instead most likely due to direct inhibition of P-gp efflux.
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Histamine Receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number2050747-49-2
-
分子量517.633
-
分子式C32H31N5O2
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 16.67 mg/mL (32.21 mM)
-
SMILESCOc1cc2CCN(CCc3ccc(Nc4nc(nc5ccccc45)-c4ccncc4)cc3)Cc2cc1OC
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Miura M, Uno T. Clinical pharmacokinetics of fexofenadine enantiomers. Expert Opin Drug Metab Toxicol. 2010 Jan;6(1):69-74.
产品手册




关联产品
-
Methoxatin disodium ...
Methoxatin disodium salt 是一种芳香族三环邻醌,是细菌脱氢酶的氧化还原辅助因子。它是一种从多种有机底物到分子氧 (O2) 的高效电子转移催化剂,可构建醌蛋白模型反应。
-
Calcium lactate
饮料工业使用乳酸钙作为钙源来强化果汁。乳酸钙促进豆芽的生长和植酸降解。
-
WAY-324820-A
WAY-324820-A 可用作 QSAR 模型,利用多元线性回归研究甲硫氨酸氨基肽酶抑制剂作为抗癌化合物。